基质辅助激光解吸/电离-飞行时间质谱(MALDI-TOF MS)是一种新型的软电离生物质谱技术,其对小分子化合物的分析一直是研究热点。目前,已经有多种新型基质材料被开发,主要分为纳米材料基质、有机小分子基质和有机聚合物基质。新型基质材料的提出,解决了传统基质的强背景离子干扰的问题,但仍处于研究阶段。综述了不同新型基质材料的优点、性质及适用对象,并对新型基质材料的未来发展趋势进行了展望。
Matrix-assisted laser desorption/ionization-time-of-flight mass spectrometry (MALDI-TOF MS) is a novel soft ionization mass spectrometry technology.Its analysis of small molecule compounds has been a research hotspot.At present,a variety of new matrices have been developed,which are mainly divided into nanomaterial matrix,organic small molecule matrix and organic polymer matrix.The new matrix has solved the traditional matrix's problem of strong background ion interference,but still at the research stage.The advantages,properties and applicable objects of different new matrices were reviewed,and prospected the future development trend of new matrices.
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基金资助
国家重点研发计划资助(2017YFF0211301)
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